PMID:15811633
| Citation |
Bridges, BA (2005) Error-prone DNA repair and translesion synthesis: focus on the replication fork. DNA Repair (Amst.) 4:618-9, 634 |
|---|---|
| Abstract |
Dean Rupp and Paul Howard-Flanders showed that, following exposure to ultraviolet light, bacteria deficient in nucleotide excision repair synthesised DNA with minimal delay and in pieces roughly the size of the distances between pyrimidine dimmers. The discontinuities or gaps between these pieces were subsequently sealed. This led directly to the hypothesis of translesion synthesis. |
| Links |
PubMed Online version:10.1016/j.dnarep.2004.11.005 |
| Keywords |
Bacteriophage lambda/genetics; Bacteriophage lambda/radiation effects; DNA/isolation & purification; DNA/metabolism; DNA/radiation effects; DNA Damage; DNA Repair; DNA Replication; Escherichia coli/genetics; Escherichia coli/radiation effects; Pyrimidine Dimers/analysis; SOS Response (Genetics); Ultraviolet Rays |
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