PMID:15757509

Citation	Serres, MH and Riley, M (2005) Gene fusions and gene duplications: relevance to genomic annotation and functional analysis. BMC Genomics 6:33
Abstract	Escherichia coli a model organism provides information for annotation of other genomes. Our analysis of its genome has shown that proteins encoded by fused genes need special attention. Such composite (multimodular) proteins consist of two or more components (modules) encoding distinct functions. Multimodular proteins have been found to complicate both annotation and generation of sequence similar groups. Previous work overstated the number of multimodular proteins in E. coli. This work corrects the identification of modules by including sequence information from proteins in 50 sequenced microbial genomes.
Links	PubMed PMC555942 Online version:10.1186/1471-2164-6-33
Keywords	Computational Biology/methods; Escherichia coli/genetics; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/metabolism; Gene Duplication; Genome; Genome, Bacterial; Genomics/methods; Ligands; Models, Genetic; Protein Structure, Tertiary; Sequence Analysis, DNA; Species Specificity
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