PMID:15728929

Citation	Stubbings, W, Bostock, J, Ingham, E and Chopra, I (2005) Deletion of the multiple-drug efflux pump AcrAB in Escherichia coli prolongs the postantibiotic effect. Antimicrob. Agents Chemother. 49:1206-8
Abstract	The mechanism of the postantibiotic effect (PAE) was examined in Escherichia coli. Drugs exhibited longer-lasting PAEs in an acrAB mutant, suggesting that intracellular drug concentrations influence the duration of the PAE. With specific assays for tetracycline and erythromycin, a direct link between intracellular persistence of antibiotics and maintenance of the PAE was established.
Links	PubMed PMC549255 Online version:10.1128/AAC.49.3.1206-1208.2005
Keywords	Anti-Bacterial Agents/pharmacology; Carrier Proteins/physiology; Erythromycin/pharmacology; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/physiology; Lipoproteins/physiology; Membrane Proteins/physiology; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Tetracycline/pharmacology; Time Factors
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