PMID:15687218
| Citation |
Kadokura, H, Nichols, L 2nd and Beckwith, J (2005) Mutational alterations of the key cis proline residue that cause accumulation of enzymatic reaction intermediates of DsbA, a member of the thioredoxin superfamily. J. Bacteriol. 187:1519-22 |
|---|---|
| Abstract |
The DsbA-DsbB pathway introduces disulfide bonds into newly translocated proteins. Conversion of the conserved cis proline 151 of DsbA to several hydrophilic residues results in accumulation of mixed disulfides between DsbA and its dedicated oxidant, DsbB. However, only a proline-to-threonine change causes accumulation of mixed disulfides of DsbA with its substrates. |
| Links |
PubMed PMC545618 Online version:10.1128/JB.187.4.1519-1522.2005 |
| Keywords |
Amino Acid Substitution; Disulfides/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Mutation, Missense; Proline/genetics; Proline/physiology; Protein Disulfide-Isomerases/genetics; Protein Disulfide-Isomerases/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.