PMID:15673787

Citation	Bohnert, JA and Kern, WV (2005) Selected arylpiperazines are capable of reversing multidrug resistance in Escherichia coli overexpressing RND efflux pumps. Antimicrob. Agents Chemother. 49:849-52
Abstract	Several arylpiperazines capable of reversing multidrug resistance (MDR) in Escherichia coli overexpressing acrAB and acrEF but not in pump-deficient mutant strains were identified. 1-(1-Naphthylmethyl)-piperazine, one of the more active compounds, enhanced susceptibility to fluoroquinolones and other agents and increased the intracellular concentration of levofloxacin and ethidium bromide, suggesting efflux pump inhibition as the mechanism of MDR reversal.
Links	PubMed PMC547223 Online version:10.1128/AAC.49.2.849-852.2005
Keywords	Anti-Bacterial Agents/pharmacology; Bacterial Proteins/genetics; Carrier Proteins/genetics; Drug Resistance, Multiple, Bacterial/genetics; Drug Resistance, Multiple, Bacterial/physiology; Escherichia coli/drug effects; Escherichia coli/genetics; Microbial Sensitivity Tests; Mutation/genetics; Ofloxacin/pharmacology; Piperazines/chemistry; Piperazines/pharmacology; Structure-Activity Relationship
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