PMID:15659541
| Citation |
Sanschagrin, F and Levesque, RC (2005) A specific peptide inhibitor of the class B metallo-beta-lactamase L-1 from Stenotrophomonas maltophilia identified using phage display. J. Antimicrob. Chemother. 55:252-5 |
|---|---|
| Abstract |
In Gram-negative bacteria, resistance to beta-lactam antibiotics and to known inhibitors mediated by metallo-beta-lactamases is a major concern and a serious threat to public health. Since no clinically useful inhibitors are available against class B metallo-beta-lactamases, the aim of the study was to identify peptides as inhibitors. |
| Links |
PubMed Online version:10.1093/jac/dkh550 |
| Keywords |
Bacterial Proteins/antagonists & inhibitors; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Enzyme Inhibitors/pharmacology; Peptide Library; Sequence Analysis, Protein/methods; Stenotrophomonas maltophilia/enzymology; beta-Lactamases/antagonists & inhibitors; beta-Lactamases/genetics; beta-Lactamases/metabolism |
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