PMID:1560462
| Citation |
Pascarella, S and Argos, P (1992) Analysis of insertions/deletions in protein structures. J. Mol. Biol. 224:461-71 |
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| Abstract |
An analysis of insertions and deletions (indels) occurring in a databank of multiple sequence alignments based on protein tertiary structure is reported. Indels prefer to be short (1 to 5 residues). The average intervening sequence length between them versus the percentage of residue identity in pairwise alignments shows an exponential behaviour, suggesting a stochastic process such that nearly every loop in an ancestral structure is a possible target for indels during evolution. The results also suggest a limit to the average size of indels accommodated by protein structures. The preferred indel conformations are reverse turn and coil as are the preferred conformations at the indel edges (N- and C-terminal sides). Interruptions in helices and strands were observed as very rare events. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Databases, Factual; Humans; Models, Molecular; Molecular Sequence Data; Mutation; Proteins/chemistry; Proteins/genetics; Sequence Alignment |
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