PMID:15603590

Citation	Ma, HW, Buer, J and Zeng, AP (2004) Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach. BMC Bioinformatics 5:199
Abstract	Cellular functions are coordinately carried out by groups of genes forming functional modules. Identifying such modules in the transcriptional regulatory network (TRN) of organisms is important for understanding the structure and function of these fundamental cellular networks and essential for the emerging modular biology. So far, the global connectivity structure of TRN has not been well studied and consequently not applied for the identification of functional modules. Moreover, network motifs such as feed forward loop are recently proposed to be basic building blocks of TRN. However, their relationship to functional modules is not clear.
Links	PubMed PMC544888 Online version:10.1186/1471-2105-5-199
Keywords	Amino Acid Motifs; Base Composition; Cluster Analysis; Computational Biology/methods; DNA, Bacterial; Escherichia coli/metabolism; Escherichia coli Proteins/chemistry; Gene Expression Regulation, Bacterial; Genes, Bacterial; Genes, Regulator; Models, Biological; Software; Systems Biology; Transcription, Genetic
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