PMID:15590624
| Citation |
Kurihara, S, Oda, S, Kato, K, Kim, HG, Koyanagi, T, Kumagai, H and Suzuki, H (2005) A novel putrescine utilization pathway involves gamma-glutamylated intermediates of Escherichia coli K-12. J. Biol. Chem. 280:4602-8 |
|---|---|
| Abstract |
A novel bacterial putrescine utilization pathway was discovered. Seven genes, the functions of whose products were not known, are involved in this novel pathway. Five of them encode enzymes that catabolize putrescine; one encodes a putrescine importer, and the other encodes a transcriptional regulator. This novel pathway involves six sequential steps as follows: 1) import of putrescine; 2) ATP-dependent gamma-glutamylation of putrescine; 3) oxidization of gamma-glutamylputrescine; 4) dehydrogenation of gamma-glutamyl-gamma-aminobutyraldehyde; 5) hydrolysis of the gamma-glutamyl linkage of gamma-glutamyl-gamma-aminobutyrate; and 6) transamination of gamma-aminobutyrate to form the final product of this pathway, succinate semialdehyde, which is the precursor of succinate. |
| Links |
PubMed Online version:10.1074/jbc.M411114200 |
| Keywords |
Adenosine Triphosphate/metabolism; Biological Transport; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Hydrolysis; Magnetic Resonance Spectroscopy; Mass Spectrometry; Membrane Transport Proteins/genetics; Membrane Transport Proteins/metabolism; Models, Biological; Multigene Family; Oxygen/metabolism; Plasmids/metabolism; Propylamines/chemistry; Protein Structure, Tertiary; Pseudomonas/metabolism; Putrescine/chemistry; Putrescine/metabolism; Succinic Acid/chemistry; Time Factors |
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