PMID:15588282

Citation	Hinds, T and Sandler, SJ (2004) Allele specific synthetic lethality between priC and dnaAts alleles at the permissive temperature of 30 degrees C in E. coli K-12. BMC Microbiol. 4:47
Abstract	DnaA is an essential protein in the regulation and initiation of DNA replication in many bacteria. It forms a protein-DNA complex at oriC to which DnaC loads DnaB. DNA replication forks initiated at oriC by DnaA can collapse on route to the terminus for a variety of reasons. PriA, PriB, PriC, DnaT, Rep and DnaC form multiple pathways to restart repaired replication forks. DnaC809 and dnaC809,820 are suppressors of priA2::kan mutant phenotypes. The former requires PriC and Rep while the latter is independent of them. RnhA339::cat mutations allow DnaA-independent initiation of DNA replication.
Links	PubMed PMC539235 Online version:10.1186/1471-2180-4-47
Keywords	Alleles; Bacterial Proteins/genetics; Bacterial Proteins/physiology; DNA Replication; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Escherichia coli K12/genetics; Escherichia coli K12/physiology; Escherichia coli Proteins/genetics; Escherichia coli Proteins/physiology; Gene Expression Regulation, Bacterial; Genes, Lethal/physiology; Mutation; Temperature
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