PMID:15567273

Citation	Bronstein, P, Marrichi, M and DeLisa, MP (2004) Dissecting the twin-arginine translocation pathway using genome-wide analysis. Res. Microbiol. 155:803-10
Abstract	A recently discovered route for protein export, known as the twin-arginine translocation (Tat) pathway, has received much attention owing to several atypical characteristics that distinguish it from other transport mechanisms. For instance, recent evidence has clearly established that this pathway only transports folded polypeptides. Moreover, several studies have demonstrated a vital role for the Tat pathway in bacterial pathogenesis. In this review, we discuss genomic approaches that have been employed to determine the prevalence and capacity of the Tat system and how the information generated from these approaches is helping to connect Tat transport to bacterial physiology and virulence.
Links	PubMed Online version:10.1016/j.resmic.2004.06.013
Keywords	Bacteria/genetics; Bacteria/metabolism; Bacterial Translocation; Escherichia coli Proteins/metabolism; Genome, Bacterial; Membrane Transport Proteins/metabolism; Protein Sorting Signals; Protein Transport
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