PMID:15556628

Citation	Turner, IJ, Scott, DJ, Allen, S, Roberts, CJ and Soultanas, P (2004) The Bacillus subtilis DnaD protein: a putative link between DNA remodeling and initiation of DNA replication. FEBS Lett. 577:460-4
Abstract	The Bacillus subtilis DnaD protein is an essential protein and a component of the oriC and PriA primosomal cascades, which are responsible for loading the main replicative ring helicase DnaC onto DNA. We present evidence that DnaD also has a global DNA architectural activity, assembling into large nucleoprotein complexes on a plasmid and counteracting plasmid compaction in a manner analogous to that recently seen for the histone-like Escherichia coli HU proteins. This DNA-remodeling role may be an essential function for initiation of DNA replication in the Gram +ve B. subtilis, thus highlighting DnaD as the link between bacterial nucleoid reorganization and initiation of DNA replication.
Links	PubMed PMC3033577 Online version:10.1016/j.febslet.2004.10.051
Keywords	Bacillus subtilis/chemistry; Bacillus subtilis/genetics; Bacillus subtilis/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/isolation & purification; Bacterial Proteins/metabolism; Chromatography, Gel; DNA Helicases/genetics; DNA Helicases/metabolism; DNA Replication; DNA, Bacterial; DNA-Binding Proteins/genetics; DNA-Binding Proteins/isolation & purification; DNA-Binding Proteins/metabolism; Microscopy, Atomic Force; Models, Biological; Ultracentrifugation
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