PMID:15546660

Citation	van Dalen, A and de Kruijff, B (2004) The role of lipids in membrane insertion and translocation of bacterial proteins. Biochim. Biophys. Acta 1694:97-109
Abstract	Phospholipids are essential building blocks of membranes and maintain the membrane permeability barrier of cells and organelles. They provide not only the bilayer matrix in which the functional membrane proteins reside, but they also can play direct roles in many essential cellular processes. In this review, we give an overview of the lipid involvement in protein translocation across and insertion into the Escherichia coli inner membrane. We describe the key and general roles that lipids play in these processes in conjunction with the protein components involved. We focus on the Sec-mediated insertion of leader peptidase. We describe as well the more direct roles that lipids play in insertion of the small coat proteins Pf3 and M13. Finally, we focus on the role of lipids in membrane assembly of oligomeric membrane proteins, using the potassium channel KcsA as model protein. In all cases, the anionic lipids and lipids with small headgroups play important roles in either determining the efficiency of the insertion and assembly process or contributing to the directionality of the insertion process.
Links	PubMed Online version:10.1016/j.bbamcr.2004.03.007
Keywords	Cell Membrane/physiology; Escherichia coli Proteins/metabolism; Escherichia coli Proteins/physiology; Membrane Lipids/metabolism; Membrane Lipids/physiology; Membrane Proteins/metabolism; Membrane Proteins/physiology; Protein Transport/physiology
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