PMID:15546656

Citation	Dalbey, RE and Chen, M (2004) Sec-translocase mediated membrane protein biogenesis. Biochim. Biophys. Acta 1694:37-53
Abstract	Alpha-helical transmembrane proteins in bacteria are localized within the plasma membrane. The membrane assembly of these proteins requires protein devices for insertion into the lipid bilayer. In E. coli, membrane proteins require the SRP pathway components Ffh, 4.5S RNA and FtsY for membrane targeting and the SecYEGDF translocase and, in some cases, SecA, for translocation of hydrophilic domains. In addition, YidC, a recently discovered membrane protein, mediates the membrane integration and folding of hydrophobic domains of membrane proteins. In this review, we will describe the current status of the protein targeting and membrane integration pathways.
Links	PubMed Online version:10.1016/j.bbamcr.2004.03.009
Keywords	Adenosine Triphosphatases/metabolism; Animals; Bacterial Proteins/metabolism; Cell Membrane/physiology; Gram-Negative Bacteria/physiology; Membrane Proteins/metabolism; Membrane Transport Proteins/metabolism; Protein Folding; Protein Transport/physiology
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.