PMID:15535863
| Citation |
Peter, BJ, Arsuaga, J, Breier, AM, Khodursky, AB, Brown, PO and Cozzarelli, NR (2004) Genomic transcriptional response to loss of chromosomal supercoiling in Escherichia coli. Genome Biol. 5:R87 |
|---|---|
| Abstract |
The chromosome of Escherichia coli is maintained in a negatively supercoiled state, and supercoiling levels are affected by growth phase and a variety of environmental stimuli. In turn, supercoiling influences local DNA structure and can affect gene expression. We used microarrays representing nearly the entire genome of Escherichia coli MG1655 to examine the dynamics of chromosome structure. |
| Links |
PubMed PMC545778 Online version:10.1186/gb-2004-5-11-r87 |
| Keywords |
Base Composition/genetics; Chromosomes, Bacterial/genetics; Codon, Initiator/genetics; Coumarins/pharmacology; DNA Topoisomerases/deficiency; DNA Topoisomerases/genetics; DNA Topoisomerases/physiology; DNA, Bacterial/genetics; DNA, Superhelical/genetics; Enzyme Inhibitors/pharmacology; Escherichia coli K12/enzymology; Escherichia coli K12/genetics; Gene Expression Profiling/methods; Gene Expression Profiling/statistics & numerical data; Gene Expression Regulation, Bacterial/genetics; Gene Expression Regulation, Bacterial/physiology; Genes, Bacterial/genetics; Genes, Bacterial/physiology; Kinetics; Mutation/genetics; Mutation/physiology; Norfloxacin/pharmacology; Oligonucleotide Array Sequence Analysis/methods; Oligonucleotide Array Sequence Analysis/statistics & numerical data; Topoisomerase Inhibitors; Transcription, Genetic/genetics |
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