PMID:15531617
| Citation |
Chabalier, J, Capponi, C, Quentin, Y and Fichant, G (2005) ISYMOD: a knowledge warehouse for the identification, assembly and analysis of bacterial integrated systems. Bioinformatics 21:1246-56 |
|---|---|
| Abstract |
Complex biological functions emerge from interactions between proteins in stable supra-molecular assemblies and/or through transitory contacts. Most of the time protein partners of the assemblies are composed of one or several domains which exhibit different biochemical functions. Thus the study of cellular process requires the identification of different functional units and their integration in an interaction network; such complexes are referred to as integrated systems. In order to exploit with optimum efficiency the increased release of data, automated bioinformatics strategies are needed to identify, reconstruct and model such systems. For that purpose, we have developed a knowledge warehouse dedicated to the representation and acquisition of bacterial integrated systems involved in the exchange of the bacterial cell with its environment. |
| Links |
PubMed Online version:10.1093/bioinformatics/bti137 |
| Keywords |
ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Algorithms; Artificial Intelligence; Database Management Systems; Databases, Genetic; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Profiling/methods; Gene Expression Regulation, Bacterial/physiology; Information Storage and Retrieval/methods; Models, Biological; Oligonucleotide Array Sequence Analysis/methods; Pattern Recognition, Automated/methods; Systems Integration |
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