PMID:15516575

Citation	Batchelor, E, Silhavy, TJ and Goulian, M (2004) Continuous control in bacterial regulatory circuits. J. Bacteriol. 186:7618-25
Abstract	We show that for two well-characterized regulatory circuits in Escherichia coli, Tn10 tetracycline resistance and porin osmoregulation, the transcriptional outputs in individual cells are graded functions of the applied stimuli. These systems are therefore examples of naturally occurring regulatory circuits that exhibit continuous control of transcription. Surprisingly, however, we find that porin osmoregulation is open loop; i.e., the porin expression level does not feed back into the regulatory circuit. This mode of control is particularly interesting for an organism such as E. coli, which proliferates in diverse environments, and raises important questions regarding the biologically relevant inputs and outputs for this system.
Links	PubMed PMC524909 Online version:10.1128/JB.186.22.7618-7625.2004
Keywords	Culture Media; DNA Transposable Elements/genetics; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Gene Deletion; Gene Expression Regulation, Bacterial; Porins/genetics; Porins/metabolism; Tetracycline Resistance/genetics; Transcription, Genetic; Water-Electrolyte Balance
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.