PMID:15505073

Citation	Armstrong, JS, Whiteman, M, Yang, H, Jones, DP and Sternberg, P Jr (2004) Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells. Invest. Ophthalmol. Vis. Sci. 45:4183-9
Abstract	Glutathione (GSH) plays a key role in protection against oxidative stress. L-cysteine is thought to be rate-limiting for the synthesis of glutathione (GSH) and therefore may be a critical component in protection against oxidative stress. The purpose of this study was to investigate the role of L-cysteine in GSH metabolism and oxidative stress in human retinal pigment epithelial (hRPE) cells.
Links	PubMed Online version:10.1167/iovs.04-0570
Keywords	Apoptosis; Cell Survival; Cells, Cultured; Cysteine/physiology; DNA/analysis; Electron Transport Complex III/metabolism; Enzyme Inhibitors/pharmacology; Glutathione/metabolism; Humans; Membrane Potentials; Mitochondria/metabolism; Oxidation-Reduction; Oxidative Stress; Permeability; Pigment Epithelium of Eye/metabolism; Pigment Epithelium of Eye/ultrastructure; Reactive Oxygen Species/metabolism
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