PMID:15498552

Citation	Wilmot, CM, Saysell, CG, Blessington, A, Conn, DA, Kurtis, CR, McPherson, MJ, Knowles, PF and Phillips, SE (2004) Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine. FEBS Lett. 576:301-5
Abstract	The X-ray crystal structure of the copper-containing quinoprotein amine oxidase from E. coli has been determined in complex with the antidepressant drug tranylcypromine to 2.4 A resolution. The drug is a racemic mix of two enantiomers, but only one is seen bound to the enzyme. The other enantiomer is not acting as a substrate for the enzyme as no catalytic activity was detected when the enzyme was initially exposed to the drug. The inhibition of human copper amine oxidases could be a source of side-effects in its use as an antidepressant to inhibit the flavin-containing monoamine oxidases in the brain.
Links	PubMed Online version:10.1016/j.febslet.2004.09.031
Keywords	Amine Oxidase (Copper-Containing)/chemistry; Amine Oxidase (Copper-Containing)/metabolism; Antidepressive Agents/chemistry; Antidepressive Agents/metabolism; Binding Sites; Crystallography, X-Ray/methods; Escherichia coli/enzymology; Models, Molecular; Tranylcypromine/chemistry; Tranylcypromine/metabolism
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.