PMID:15474018

Citation	van Bloois, E, Jan Haan, G, de Gier, JW, Oudega, B and Luirink, J (2004) F(1)F(0) ATP synthase subunit c is targeted by the SRP to YidC in the E. coli inner membrane. FEBS Lett. 576:97-100
Abstract	Escherichia coli inner membrane proteins (IMPs) use different pathways for targeting and membrane integration. We have examined the biogenesis of the F1F0 ATP synthase subunit c, a small double spanning IMP, using complementary in vivo and in vitro approaches. The data suggest that F0c is targeted by the SRP to the membrane, where it inserts at YidC in a Sec-independent mechanism. F0c appears to be the first natural substrate of this novel pathway.
Links	PubMed Online version:10.1016/j.febslet.2004.08.069
Keywords	Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Membrane Transport Proteins/metabolism; Mitochondrial Proton-Translocating ATPases/chemistry; Protein Subunits/metabolism; Signal Recognition Particle/metabolism
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