PMID:1543504
| Citation |
Nummer, BA, Barefoot, SF and Kline, EL (1992) Effects of the flrA regulatory locus on biosynthesis and excretion of amino acids in Escherichia coli B/r. Biochem. Biophys. Res. Commun. 183:343-9 |
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| Abstract |
We have partially characterized phenotypic effects of an unusual amino acid regulatory locus, flrA, in E. coli B/r that alters the expression of the ilv and leu operons [Kline, E.L (1972) J. Bacteriol. 110:1127-1134]. This study demonstrated that a primary effect of the flrA7 mutation in haploid strains was overproduction of valine. In diploid strains (FflrA+/flrA7) this mutation resulted in excretion of valine, isoleucine, leucine, aspartate, threonine, glutamate, histidine and lysine. Increased excretion of amino acids by mutant strains might be explained by a membrane alteration or by flrA encoding a positive regulatory factor that affects the ilv operon and has pleiotropic effects on other amino acid operons. |
| Links | |
| Keywords |
2-Isopropylmalate Synthase/metabolism; Alanine/metabolism; Amino Acids/metabolism; Escherichia coli/genetics; Genes, Bacterial/genetics; Genes, Regulator/genetics; Isoleucine/metabolism; Leucine/metabolism; RNA, Transfer, Leu/metabolism; Transfer RNA Aminoacylation; Valine/metabolism |
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