PMID:15377501

Citation	Ott, S, Hansen, A, Kim, SY and Miyano, S (2005) Superiority of network motifs over optimal networks and an application to the revelation of gene network evolution. Bioinformatics 21:227-38
Abstract	Estimating the network of regulative interactions between genes from gene expression measurements is a major challenge. Recently, we have shown that for gene networks of up to around 35 genes, optimal network models can be computed. However, even optimal gene network models will in general contain false edges, since the expression data will not unambiguously point to a single network.
Links	PubMed Online version:10.1093/bioinformatics/bth484
Keywords	Algorithms; Bacillus subtilis/physiology; Bacterial Proteins/metabolism; Computer Simulation; Escherichia coli/physiology; Escherichia coli Proteins/physiology; Gene Expression Profiling/methods; Gene Expression Regulation/physiology; Models, Genetic; Oligonucleotide Array Sequence Analysis/methods; Signal Transduction/physiology; Software; Transcription Factors/metabolism
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