PMID:15375374

Citation	Flores, MJ, Bidnenko, V and Michel, B (2004) The DNA repair helicase UvrD is essential for replication fork reversal in replication mutants. EMBO Rep. 5:983-8
Abstract	Replication forks arrested by inactivation of the main Escherichia coli DNA polymerase (polymerase III) are reversed by the annealing of newly synthesized leading- and lagging-strand ends. Reversed forks are reset by the action of RecBC on the DNA double-strand end, and in the absence of RecBC chromosomes are linearized by the Holliday junction resolvase RuvABC. We report here that the UvrD helicase is essential for RuvABC-dependent chromosome linearization in E. coli polymerase III mutants, whereas its partners in DNA repair (UvrA/B and MutL/S) are not. We conclude that UvrD participates in replication fork reversal in E. coli.
Links	PubMed PMC1299159 Online version:10.1038/sj.embor.7400262
Keywords	Adenosine Triphosphatases/metabolism; DNA Damage/physiology; DNA Helicases/metabolism; DNA Polymerase III/metabolism; DNA Repair/physiology; DNA Replication/genetics; DNA Replication/physiology; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins/metabolism; Exodeoxyribonuclease V/metabolism; Mutation
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