PMID:15351395

Citation	Jennings, LD, Foreman, KW, Rush, TS 3rd, Tsao, DH, Mosyak, L, Kincaid, SL, Sukhdeo, MN, Sutherland, AG, Ding, W, Kenny, CH, Sabus, CL, Liu, H, Dushin, EG, Moghazeh, SL, Labthavikul, P, Petersen, PJ, Tuckman, M, Haney, SA and Ruzin, AV (2004) Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction. Bioorg. Med. Chem. 12:5115-31
Abstract	The ZipA-FtsZ protein-protein interaction is a potential target for antibacterial therapy. The design and parallel synthesis of a combinatorial library of small molecules, which target the FtsZ binding area on ZipA are described. Compounds were demonstrated to bind to the FtsZ binding domain of ZipA by HSQC NMR and to inhibit cell division in a cell elongation assay.
Links	PubMed Online version:10.1016/j.bmc.2004.07.031
Keywords	Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/pharmacology; Carrier Proteins/chemistry; Cell Cycle Proteins/chemistry; Cell Division/drug effects; Combinatorial Chemistry Techniques; Escherichia coli/cytology; Escherichia coli/drug effects; Escherichia coli Proteins/chemistry; Indoles/chemical synthesis; Indoles/pharmacology; Inhibitory Concentration 50; Piperidines/chemical synthesis; Piperidines/pharmacology; Protein Binding/drug effects; Structure-Activity Relationship
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