PMID:1534139

Citation	Bolshakova, TN, Molchanova, ML, Erlagaeva, RS, Grigorenko, YA and Gershanovitch, VN (1992) A novel mutation FruS, altering synthesis of components of the phosphoenolpyruvate: fructose phosphotransferase system in Escherichia coli K12. Mol. Gen. Genet. 232:394-8
Abstract	A novel mutation, FruS localised in the fru operon was obtained. It uncouples expression of the genes determining synthesis of the fructose-specific transport proteins and fructose-1-phosphate kinase. In FruS bacteria the fruA and fruF genes (coding for Enzyme IIfru and FPr, respectively) are constitutive by expressed while fruK (encoding fructose-1-phosphate kinase) remains inducible. In contrast to other mutations, which render expression of the whole fru operon constitutive, the FruS mutation: (1) does not lead to D-xylitol sensitivity; (2) does not inhibit growth on D-lactate, pyruvate and L-alanine; (3) does not decrease phosphoenolpyruvate (PEP) synthase activity.
Links	PubMed
Keywords	Alanine/metabolism; Enzyme Induction; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Genes, Bacterial; Genotype; Lactates/metabolism; Mannose/metabolism; Mutagenesis, Insertional; Operon; Phosphoenolpyruvate Sugar Phosphotransferase System/genetics; Phosphofructokinase-1/genetics; Phosphofructokinase-1/metabolism; Pyruvates/metabolism; Transduction, Genetic; Xylitol/metabolism
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