PMID:15328143

Citation	Chollet, R, Chevalier, J, Bryskier, A and Pagès, JM (2004) The AcrAB-TolC pump is involved in macrolide resistance but not in telithromycin efflux in Enterobacter aerogenes and Escherichia coli. Antimicrob. Agents Chemother. 48:3621-4
Abstract	The role of the AcrAB-TolC pump in macrolide and ketolide susceptibility in Escherichia coli and Enterobacter aerogenes was studied. Efflux pump inhibitor restored erythromycin, clarithromycin, and telithromycin susceptibilities to multidrug-resistant isolates. No modification of telithromycin accumulation was detected in E. aerogenes acrAB or tolC derivatives compared to that in the parental strain. Two independent efflux pumps, inhibited by phenylalanine arginine beta-naphthylamide, expel macrolides and telithromycin in E. aerogenes.
Links	PubMed PMC514773 Online version:10.1128/AAC.48.9.3621-3624.2004
Keywords	Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Arginine/analogs & derivatives; Arginine/pharmacology; Bacterial Outer Membrane Proteins/antagonists & inhibitors; Bacterial Outer Membrane Proteins/metabolism; Bacterial Outer Membrane Proteins/physiology; Dose-Response Relationship, Drug; Drug Resistance, Bacterial/genetics; Enterobacter aerogenes/drug effects; Enterobacter aerogenes/metabolism; Enterobacter aerogenes/pathogenicity; Erythromycin/pharmacology; Escherichia coli/drug effects; Escherichia coli/metabolism; Escherichia coli/pathogenicity; Escherichia coli Proteins; Ketolides; Macrolides/metabolism; Macrolides/pharmacology; Membrane Transport Proteins; Microbial Sensitivity Tests
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