PMID:15317805

Citation	Sugai, R, Shimizu, H, Nishiyama, K and Tokuda, H (2004) Overexpression of gnsA, a multicopy suppressor of the secG null mutation, increases acidic phospholipid contents by inhibiting phosphatidylethanolamine synthesis at low temperatures. J. Bacteriol. 186:5968-71
Abstract	GnsA overproduction was previously found to suppress both the secG null mutation and the fabA6 mutation in Escherichia coli by increasing the unsaturated fatty acid contents. We report here that it also increased the acidic phospholipid contents at 20 degrees C but not at 37 degrees C. GnsA overproduction at 20 degrees C specifically inhibited phosphatidylethanolamine synthesis and therefore caused the increase in the proportion of acidic phospholipids.
Links	PubMed PMC516848 Online version:10.1128/JB.186.17.5968-5971.2004
Keywords	Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Escherichia coli Proteins/physiology; Fatty Acid Synthetase Complex, Type II; Fatty Acids, Unsaturated/analysis; Genes, Bacterial; Hydro-Lyases/genetics; Hydro-Lyases/physiology; Membrane Proteins/genetics; Membrane Proteins/physiology; Phosphatidylethanolamines/biosynthesis; Phosphatidylethanolamines/genetics; Phospholipids/analysis; Phospholipids/biosynthesis; Temperature
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