PMID:15313234

Citation	Abramson, J, Kaback, HR and Iwata, S (2004) Structural comparison of lactose permease and the glycerol-3-phosphate antiporter: members of the major facilitator superfamily. Curr. Opin. Struct. Biol. 14:413-9
Abstract	Structural knowledge of the major facilitator superfamily has dramatically increased during the past year with the emergence of the structures of three members of this family of transporters. All three structures reveal 12 transmembrane helices forming two distinct domains, and could imply that members of this superfamily have preserved both secondary and tertiary structure elements during evolution.
Links	PubMed Online version:10.1016/j.sbi.2004.07.005
Keywords	Binding Sites; Escherichia coli/metabolism; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/metabolism; Membrane Transport Proteins/chemistry; Membrane Transport Proteins/metabolism; Models, Molecular; Monosaccharide Transport Proteins/chemistry; Monosaccharide Transport Proteins/metabolism; Protein Structure, Tertiary; Protein Transport/physiology; Structure-Activity Relationship; Substrate Specificity; Symporters/chemistry; Symporters/metabolism
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