PMID:15265237

Citation	Riva, A, Delorme, MO, Chevalier, T, Guilhot, N, Hénaut, C and Hénaut, A (2004) Characterization of the GATC regulatory network in E. coli. BMC Genomics 5:48
Abstract	The tetranucleotide GATC is methylated in Escherichia. coli by the DNA methyltransferase (Dam) and is known to be implicated in numerous cellular processes. Mutants lacking Dam are characterized by a pleiotropic phenotype. The existence of a GATC regulated network, thought to be involved in cold and oxygen shift, had been proposed and its existence has recently been confirmed. The aim of this article is to describe the components of the GATC regulated network of E. coli in detail and propose a role of this network in the light of an evolutionary advantage for the organism.
Links	PubMed PMC493266 Online version:10.1186/1471-2164-5-48
Keywords	Biological Evolution; Cold Temperature; Energy Metabolism/genetics; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins/physiology; Fatty Acids/metabolism; Gene Expression Regulation, Bacterial/drug effects; Mitomycin/pharmacology; Nucleotides/metabolism; Phenotype; Phospholipids/metabolism; Salmonella/genetics; Selection, Genetic; Site-Specific DNA-Methyltransferase (Adenine-Specific)/physiology; Species Specificity; Succinates/metabolism
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