PMID:15248901

Citation	Wilharm, G, Lehmann, V, Neumayer, W, Trcek, J and Heesemann, J (2004) Yersinia enterocolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretion. BMC Microbiol. 4:27
Abstract	Pathogenic Yersinia species (Y. enterocolitica, Y. pestis, Y. pseudotuberculosis) share a type three secretion system (TTSS) which allows translocation of effector proteins (called Yops) into host cells. It is believed that proteins are delivered through a hollow needle with an inner diameter of 2-3 nm. Thus transport seems to require substrates which are essentially unfolded. Recent work from different groups suggests that the Yersinia TTSS cannot accommodate substrates which are folded prior to secretion. It was suggested that folding is prevented either by co-translational secretion or by the assistance of specific Yop chaperones (called Sycs).
Links	PubMed PMC471551 Online version:10.1186/1471-2180-4-27
Keywords	Bacterial Outer Membrane Proteins/genetics; Bacterial Outer Membrane Proteins/secretion; Bacterial Proteins/secretion; Biological Transport, Active; Protein Folding; Protein Sorting Signals/genetics; Protein Sorting Signals/physiology; Recombinant Proteins/genetics; Recombinant Proteins/secretion; Tetrahydrofolate Dehydrogenase/genetics; Tetrahydrofolate Dehydrogenase/secretion; Trans-Activators/secretion; Yersinia enterocolitica/growth & development; Yersinia enterocolitica/metabolism
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