PMID:15231812

Citation	Kuban, W, Jonczyk, P, Gawel, D, Malanowska, K, Schaaper, RM and Fijalkowska, IJ (2004) Role of Escherichia coli DNA polymerase IV in in vivo replication fidelity. J. Bacteriol. 186:4802-7
Abstract	We have investigated whether DNA polymerase IV (Pol IV; the dinB gene product) contributes to the error rate of chromosomal DNA replication in Escherichia coli. We compared mutation frequencies in mismatch repair-defective strains that were either dinB positive or dinB deficient, using a series of mutational markers, including lac targets in both orientations on the chromosome. Virtually no contribution of Pol IV to the chromosomal mutation rate was observed. On the other hand, a significant effect of dinB was observed for reversion of a lac allele when the lac gene resided on an F'(pro-lac) episome.
Links	PubMed PMC438567 Online version:10.1128/JB.186.14.4802-4807.2004
Keywords	Chromosomes, Bacterial/metabolism; DNA Polymerase beta/metabolism; DNA Repair; DNA Replication; DNA, Bacterial/metabolism; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Gene Deletion; Genes, Reporter; Mutation; beta-Galactosidase/genetics; beta-Galactosidase/metabolism
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