PMID:15213244

Citation	Bae, NS, Swanson, MJ, Vassilev, A and Howard, BH (2004) Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10. J. Biochem. 135:695-700
Abstract	Histone deacetylases are required for transcriptional repression in eukaryotes. Saccharomyces cerevisiae has several histone deacetylases, of which ySir2p is the most conserved throughout evolution. Currently, there is no report on the interacting protein partner of a human Sir2 homolog, SIRT2. Here we show for the first time that SIRT2 interacts with the homeobox transcription factor, HOXA10, which was identified in a two-hybrid screen. Interactions were confirmed by co-immunoprecipitation from in vitro translations as well as in human cell-free extracts. Taken together with mouse knockout studies, our results raise the intriguing possibility that SIRT2 plays a role in mammalian development.
Links	PubMed Online version:10.1093/jb/mvh084
Keywords	Animals; Cell Line; Cell-Free System; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Homeodomain Proteins; Humans; Mice; Protein Binding; Recombinant Fusion Proteins/genetics; Recombinant Fusion Proteins/metabolism; Sirtuin 2; Sirtuins/genetics; Sirtuins/metabolism; Two-Hybrid System Techniques
edit table

Significance

You can help EcoliWiki by summarizing why this paper is useful

You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.

Add links to pages that link here (e.g. gene, product, method pages)

See Help:References for how to manage references in EcoliWiki.