PMID:15165604

Citation	Tenaillon, O, Denamur, E and Matic, I (2004) Evolutionary significance of stress-induced mutagenesis in bacteria. Trends Microbiol. 12:264-70
Abstract	Mutagenesis is often increased in bacterial populations as a consequence of stress-induced genetic pathways. Analysis of the molecular mechanisms involved suggests that mutagenesis might be increased as a by-product of the stress response of the organism. By contrast, computer simulations and analyses of stress-inducible phenotypes among natural isolates of Escherichia coli suggest that stress-induced mutagenesis (SIM) could be the result of selection because of the beneficial mutations that such a process can potentially generate. Regardless of the nature of the selective pressure acting on SIM, it is possible that the resulting increased genetic variability plays an important role in bacterial evolution.
Links	PubMed Online version:10.1016/j.tim.2004.04.002
Keywords	Adaptation, Biological; Bacteria/genetics; Bacterial Physiological Phenomena; Biological Evolution; Escherichia coli/genetics; Escherichia coli/physiology; Genetic Variation; Mutagenesis; Selection, Genetic
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