PMID:1515282
| Citation |
Norinder, U and Högberg, T (1992) PLS-based quantitative structure-activity relationship for substituted benzamides of clebopride type. Application of experimental design in drug design. Acta Chem. Scand. 46:363-6 |
|---|---|
| Abstract |
The advantageous approach of using an experimentally designed training set as the basis for establishing a quantitative structure-activity relationship with good predictive capability is described. The training set was selected from a fractional factorial design scheme based on a principal component description of physico-chemical parameters of aromatic substituents. The derived model successfully predicts the activities of additional substituted benzamides of 6-methoxy-N-(4-piperidyl)salicylamide type. The major influence on activity of the 3-substituent is demonstrated. |
| Links | |
| Keywords |
Benzamides/chemistry; Drug Design; Least-Squares Analysis; Regression Analysis; Research Design; Structure-Activity Relationship |
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