PMID:15150257

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Citation

Hazan, R, Sat, B and Engelberg-Kulka, H (2004) Escherichia coli mazEF-mediated cell death is triggered by various stressful conditions. J. Bacteriol. 186:3663-9

Abstract

mazEF is an Escherichia coli suicide module specific for a stable toxin and a labile antitoxin. Inhibiting mazEF expression appeared to activate the module to cause cell death. Here we show that several stressful conditions, including high temperatures, DNA damage, and oxidative stress, also induce mazEF-mediated cell death. We also show that this process takes place only during logarithmic growth and requires an intact relA gene.

Links

PubMed PMC415763 Online version:10.1128/JB.186.11.3663-3669.2004

Keywords

Cell Death; DNA-Binding Proteins/physiology; Endoribonucleases; Escherichia coli/physiology; Escherichia coli Proteins/physiology; Hot Temperature; Oxidative Stress

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