PMID:15113413

Citation	Light, S and Kraulis, P (2004) Network analysis of metabolic enzyme evolution in Escherichia coli. BMC Bioinformatics 5:15
Abstract	The two most common models for the evolution of metabolism are the patchwork evolution model, where enzymes are thought to diverge from broad to narrow substrate specificity, and the retrograde evolution model, according to which enzymes evolve in response to substrate depletion. Analysis of the distribution of homologous enzyme pairs in the metabolic network can shed light on the respective importance of the two models. We here investigate the evolution of the metabolism in E. coli viewed as a single network using EcoCyc.
Links	PubMed PMC394313 Online version:10.1186/1471-2105-5-15
Keywords	Algorithms; Biotin/metabolism; Computational Biology/methods; Databases, Genetic; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Escherichia coli Proteins/physiology; Evolution, Molecular; Genes, Bacterial/genetics; Genes, Bacterial/physiology; Models, Biological; Sequence Homology, Amino Acid; Substrate Specificity/genetics
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