PMID:15100012
| Citation |
Chang, CJ, Chang, MC, Damrauer, NH and Nocera, DG (2004) Proton-coupled electron transfer: a unifying mechanism for biological charge transport, amino acid radical initiation and propagation, and bond making/breaking reactions of water and oxygen. Biochim. Biophys. Acta 1655:13-28 |
|---|---|
| Abstract |
Redox-driven proton pumps, radical initiation and propagation in biology, and small-molecule activation processes all involve the coupling of electron transfer to proton transport. A mechanistic framework in which to interpret these processes is being developed by examining proton-coupled electron transfer (PCET) in model and natural systems. Specifically, PCET investigations are underway on the following three fronts: (1) the elucidation of the PCET reaction mechanism by time-resolved laser spectroscopy of electron donors and acceptors juxtaposed by a proton transfer interface; (2) the role of amino acid radicals in biological catalysis with the radical initiation and transport processes of E. coli ribonucleotide reductase (RNR) as a focal point; and (3) the application of PCET towards small-molecule activation with emphasis on biologically relevant bond-breaking and bond-making processes involving oxygen and water. A review of recent developments in each of these areas is discussed. |
| Links |
PubMed Online version:10.1016/j.bbabio.2003.08.010 |
| Keywords |
Amino Acids/metabolism; Electron Transport; Electron Transport Complex IV/metabolism; Free Radicals/metabolism; Models, Biological; Oxidation-Reduction; Oxygen/metabolism; Photolysis; Photosystem II Protein Complex/metabolism; Proton-Motive Force; Ribonucleotide Reductases/metabolism; Water/metabolism |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.