PMID:15063852

Citation	Böhm, A and Boos, W (2004) Gene regulation in prokaryotes by subcellular relocalization of transcription factors. Curr. Opin. Microbiol. 7:151-6
Abstract	Traditionally, prokaryotic transcriptional regulators were thought to be controlled by the binding of low-molecular-weight effector molecules--inducers and co-repressors. Here, we describe two examples of a novel mode of regulator control. In this mode, transcription factors "shuttle" between their operator sites on the chromosome and the inner face of the cytoplasmic membrane, where they are sequestered by specific transport systems. This change in the subcellular address corresponds to the on/off state of the target genes; thus, release or binding of the transcription regulators is controlled by the activity of these transporters.
Links	PubMed Online version:10.1016/j.mib.2004.02.009
Keywords	ATP-Binding Cassette Transporters/genetics; ATP-Binding Cassette Transporters/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial/physiology; Repressor Proteins/genetics; Repressor Proteins/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism
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