PMID:15040447

Citation	Sedgwick, B (2004) Repairing DNA-methylation damage. Nat. Rev. Mol. Cell Biol. 5:148-57
Abstract	Methylating agents modify DNA at many different sites, thereby producing lethal and mutagenic lesions. To remove all the main harmful base lesions, at least three types of DNA-repair activities can be used, each of which involves a different reaction mechanism. These activities include DNA-glycosylases, DNA-methyltransferases and the recently characterized DNA-dioxygenases. The Escherichia coli AlkB dioxygenase and the two human homologues, ABH2 and ABH3, represent a novel mechanism of DNA repair. They use iron-oxo intermediates to oxidize stable methylated bases in DNA and directly revert them to the unmodified form.
Links	PubMed Online version:10.1038/nrm1312
Keywords	Amino Acid Sequence; Animals; DNA Damage; DNA Glycosylases/metabolism; DNA Methylation; DNA Modification Methylases/metabolism; DNA Repair; DNA Repair Enzymes; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/metabolism; Humans; Mixed Function Oxygenases/chemistry; Mixed Function Oxygenases/metabolism; Models, Molecular; Molecular Sequence Data; Molecular Structure; Sequence Alignment
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