PMID:15037506

Citation	Ma, HW, Zhao, XM, Yuan, YJ and Zeng, AP (2004) Decomposition of metabolic network into functional modules based on the global connectivity structure of reaction graph. Bioinformatics 20:1870-6
Abstract	Metabolic networks are organized in a modular, hierarchical manner. Methods for a rational decomposition of the metabolic network into relatively independent functional subsets are essential to better understand the modularity and organization principle of a large-scale, genome-wide network. Network decomposition is also necessary for functional analysis of metabolism by pathway analysis methods that are often hampered by the problem of combinatorial explosion due to the complexity of metabolic network. Decomposition methods proposed in literature are mainly based on the connection degree of metabolites. To obtain a more reasonable decomposition, the global connectivity structure of metabolic networks should be taken into account.
Links	PubMed Online version:10.1093/bioinformatics/bth167
Keywords	Algorithms; Computer Graphics; Computer Simulation; Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial/physiology; Models, Biological; Signal Transduction/physiology; User-Computer Interface
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