PMID:15024097

Citation	Wiggins, P and Phillips, R (2004) Analytic models for mechanotransduction: gating a mechanosensitive channel. Proc. Natl. Acad. Sci. U.S.A. 101:4071-6
Abstract	Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich story that can provide both a quantitative comparison with measurements of opening tension for MscL when reconstituted in bilayers of different thickness, and qualitative insights into the function of the MscL channel and other transmembrane proteins.
Links	PubMed PMC384697 Online version:10.1073/pnas.0307804101
Keywords	Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Ion Channels/metabolism; Lipid Bilayers/metabolism; Mechanotransduction, Cellular/physiology; Patch-Clamp Techniques; Thermodynamics
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