PMID:14962940

Citation	Andreini, C, Bertini, I and Rosato, A (2004) A hint to search for metalloproteins in gene banks. Bioinformatics 20:1373-80
Abstract	With the advent of genome sequencing, a huge database of protein primary sequences has been accumulating. In parallel, a number of tools to investigate and expand upon this information, e.g. reconstructing and building relationships between protein families and superfamilies, have been developed. Metalloproteins are proteins capable of binding one or more metal ions, which are required for their biological function or for regulation of their activities or for structural purposes. Sometimes, metal binding can be observed in vitro but not be physiologically relevant. At present, there is a lack of specific tools to address the matter of the identification of metalloproteins in databases of gene sequences.
Links	PubMed Online version:10.1093/bioinformatics/bth095
Keywords	Algorithms; Binding Sites; Copper/analysis; Copper/chemistry; Databases, Protein; Drosophila Proteins/chemistry; Genomics/methods; Humans; Information Storage and Retrieval/methods; Metalloproteins/analysis; Metalloproteins/chemistry; Metalloproteins/classification; Protein Binding; Protein Interaction Mapping/methods; Sequence Alignment/methods; Sequence Analysis, Protein/methods; Sequence Homology, Amino Acid; Species Specificity
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