PMID:14693565
| Citation |
Poirel, L, Héritier, C and Nordmann, P (2004) Chromosome-encoded ambler class D beta-lactamase of Shewanella oneidensis as a progenitor of carbapenem-hydrolyzing oxacillinase. Antimicrob. Agents Chemother. 48:348-51 |
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| Abstract |
A chromosome-encoded beta-lactamase gene from a Shewanella oneidensis reference strain was cloned and expressed in Escherichia coli. It encoded a carbapenem-hydrolyzing Ambler class D beta-lactamase, OXA-54, that shared 92% amino acid identity with the plasmid-encoded carbapenem-hydrolyzing oxacillinase OXA-48 from Klebsiella pneumoniae. This work suggests that Shewanella spp. may produce the progenitor of oxacillinases compromising the efficacy of imipenem in clinically relevant gram-negative pathogens. |
| Links | |
| Keywords |
Amino Acid Sequence; Carbapenems/metabolism; Carrier Proteins/biosynthesis; Carrier Proteins/genetics; Carrier Proteins/metabolism; Disease Reservoirs; Escherichia coli/enzymology; Escherichia coli/metabolism; Hydrolysis; Isoelectric Focusing; Kinetics; Molecular Sequence Data; Plasmids/genetics; Shewanella/drug effects; Shewanella/enzymology; Shewanella/metabolism; beta-Lactamases/biosynthesis; beta-Lactamases/genetics; beta-Lactamases/metabolism |
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