PMID:14685315

Citation	Sutherland, AG, Alvarez, J, Ding, W, Foreman, KW, Kenny, CH, Labthavikul, P, Mosyak, L, Petersen, PJ, Rush, TS 3rd, Ruzin, A, Tsao, DH and Wheless, KL (2003) Structure-based design of carboxybiphenylindole inhibitors of the ZipA-FtsZ interaction. Org. Biomol. Chem. 1:4138-40
Abstract	Structural features of two weak inhibitors of the ZipA-FtsZ protein-protein interaction which were found to bind to overlapping but different areas of the key binding site were combined in one new series of carboxybiphenyl-indoles with improved inhibitory activity.
Links	PubMed Online version:10.1039/b312016c
Keywords	Bacterial Proteins/antagonists & inhibitors; Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Carrier Proteins/antagonists & inhibitors; Carrier Proteins/chemistry; Carrier Proteins/metabolism; Cell Cycle Proteins/antagonists & inhibitors; Cell Cycle Proteins/chemistry; Cell Cycle Proteins/metabolism; Cytoskeletal Proteins/antagonists & inhibitors; Cytoskeletal Proteins/chemistry; Cytoskeletal Proteins/metabolism; Drug Design; Escherichia coli Proteins/antagonists & inhibitors; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/metabolism; Indoles/chemistry; Indoles/pharmacology; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Protein Binding/drug effects; Protein Structure, Tertiary; Structure-Activity Relationship
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