PMID:1465385
| Citation |
Sherman, DR, Kloek, AP, Krishnan, BR, Guinn, B and Goldberg, DE (1992) Ascaris hemoglobin gene: plant-like structure reflects the ancestral globin gene. Proc. Natl. Acad. Sci. U.S.A. 89:11696-700 |
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| Abstract |
Animal globin genes have two introns at strictly conserved positions, while plant globin genes have both of these as well as an additional, central intron. It has been proposed that a common ancestor gene had three introns, one of which was subsequently lost from animal but not plant globin genes. We have elucidated the cDNA sequence and gene structure of a hemoglobin from the parasitic nematode Ascaris suum and found a plant-like central intron, providing strong evidence for a three-intron ancestor of modern globin genes. |
| Links | |
| Keywords |
Amino Acid Sequence; Animals; Ascaris/genetics; Base Sequence; Biological Evolution; DNA/genetics; Genes; Genes, Plant; Globins/genetics; Introns; Molecular Sequence Data; Oligodeoxyribonucleotides/chemistry; Polymerase Chain Reaction; Sequence Alignment |
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