PMID:1458027
| Citation |
Donachie, WD (1992) What is the minimum number of dedicated functions required for a basic cell cycle? Curr. Opin. Genet. Dev. 2:792-8 |
|---|---|
| Abstract |
The genome of Escherichia coli has a coding capacity for about 4500 proteins but only a small number of these appear to be specific for the periodic events (initiation of DNA replication, chromosome partitioning and cell division) that punctuate the cell-duplication cycle: furthermore, many of these cell cycle dedicated functions are dispensible under certain conditions, although their presence undoubtedly increases the fitness of the organism to survive in a competitive environment. A simplified but effective cell replication cycle can probably operate with only a few cycle-dedicated proteins, in addition to those required for cell growth itself. |
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| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cell Cycle/genetics; Cell Division; Cell Wall/ultrastructure; DNA Replication; DNA, Bacterial/metabolism; DNA, Fungal/metabolism; Escherichia coli/cytology; Escherichia coli/genetics; Fungal Proteins/genetics; Fungal Proteins/metabolism; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Fungal; Genes, Bacterial; Genes, Fungal; Yeasts/cytology; Yeasts/genetics |
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