PMID:14528263
| Citation |
de Gier, JW and Luirink, J (2003) The ribosome and YidC. New insights into the biogenesis of Escherichia coli inner membrane proteins. EMBO Rep. 4:939-43 |
|---|---|
| Abstract |
In the bacterium Escherichia coli, inner membrane proteins (IMPs) are generally targeted through the signal recognition particle pathway to the Sec translocon, which is capable of both linear transport into the periplasm and lateral transport into the lipid bilayer. Lateral transport seems to be assisted by the IMP YidC. In this article, we discuss recent observations that point to a key role for the ribosome in IMP targeting and to the diverse roles of YidC in IMP assembly. |
| Links |
PubMed PMC1326391 Online version:10.1038/sj.embor.embor921 |
| Keywords |
Adenosine Triphosphatases/metabolism; Bacterial Proteins/metabolism; Cell Membrane/metabolism; Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/metabolism; Membrane Transport Proteins/metabolism; Protein Transport/physiology; Ribosomes/metabolism; Signal Recognition Particle/metabolism |
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