PMID:14527653

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Citation

Falnes, PØ and Rognes, T (2003) DNA repair by bacterial AlkB proteins. Res. Microbiol. 154:531-8

Abstract

The Escherichia coli AlkB protein is an iron- and 2-oxoglutarate-dependent oxygenase, repairing 1-methyladenine and 3-methylcytosine lesions in DNA. AlkB homologues are present in a number of bacterial species, and some bacteria have two different AlkB proteins. AlkB also repairs lesions in RNA, and the biological significance of RNA repair is discussed.

Links

PubMed Online version:10.1016/S0923-2508(03)00150-5

Keywords

Adenine/analogs & derivatives; Adenine/metabolism; Alkylation; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cytosine/analogs & derivatives; Cytosine/metabolism; DNA Repair; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Mixed Function Oxygenases/genetics; Mixed Function Oxygenases/metabolism; Molecular Sequence Data; Oxygenases/genetics; Oxygenases/metabolism; Phylogeny; Sequence Alignment; Sequence Homology, Amino Acid

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