PMID:14519998
| Citation |
Sakamoto, Y, Furukawa, S, Ogihara, H and Yamasaki, M (2003) Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli. Biosci. Biotechnol. Biochem. 67:2030-3 |
|---|---|
| Abstract |
Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP. |
| Links | |
| Keywords |
Adenylate Cyclase/deficiency; Adenylate Cyclase/genetics; Anti-Bacterial Agents/metabolism; Anti-Bacterial Agents/pharmacology; Cyclic AMP/pharmacology; Drug Resistance, Microbial/genetics; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Fosfomycin/analogs & derivatives; Fosfomycin/chemistry; Fosfomycin/metabolism; Fosfomycin/pharmacology; Gene Expression Profiling; Genotype; Microbial Sensitivity Tests; Mutation; Oligonucleotide Array Sequence Analysis |
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