PMID:1438158
| Citation |
Ogiwara, A, Uchiyama, I, Seto, Y and Kanehisa, M (1992) Construction of a dictionary of sequence motifs that characterize groups of related proteins. Protein Eng. 5:479-88 |
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| Abstract |
An automatic procedure is proposed to identify, from the protein sequence database, conserved amino acid patterns (or sequence motifs) that are exclusive to a group of functionally related proteins. This procedure is applied to the PIR database and a dictionary of sequence motifs that relate to specific superfamilies constructed. The motifs have a practical relevance in identifying the membership of specific superfamilies without the need to perform sequence database searches in 20% of newly determined sequences. The sequence motifs identified represent functionally important sites on protein molecules. When multiple blocks exist in a single motif they are often close together in the 3-D structure. Furthermore, occasionally these motif blocks were found to be split by introns when the correlation with exon structures was examined. |
| Links | |
| Keywords |
Amino Acid Sequence; Databases, Factual; Models, Molecular; Molecular Sequence Data; Multigene Family; Peptides; Protein Conformation; Sequence Homology, Amino Acid |
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